At least 13 people were killed on Thursday when a passenger coach collided with a motorcycle-rickshaw on National Highway.
The incident took place near Saeed Abad Area of the Matiari District which also left three people injured.
Traffic on the National Highway was suspended as rescuers shifted the dead and the injured to a nearby hospital.
Identities of the dead and the injured were not immediately known.
Sindh Provincial Minister for Local Government Saeed Ghani has expressed grief over the incident and assured that an investigation would be carried out.